― What should your target cholesterol levels? ∙ Your cholesterol target depends on your risk of heart disease. Your doctor will calculate this risk based on your age, your gender, your cholesterol levels and your overall health. You can also determine your own risk of heart disease with our calculator target cholesterol levels and heart disease risk. Regardless of your level of risk of heart disease, the goal is to reduce your LDL ("bad" cholesterol) at least 50%. Your doctor can determine [...].